Gene expression profiling of minimally differentiated acute myeloid leukemia : M 0 is a distinct entity subdivided by RUNX 1 mutation status . Running title : GEP of AML - M 0
نویسندگان
چکیده
Fernando PG Silva, Sigrid MA Swagemakers, Claudia Erpelinck-Verschueren, Bas J Wouters, Ruud Delwel , Harry Vrieling, Peter van der Spek, Peter JM Valk & Micheline Giphart-Gassler 1 Department of Toxicogenetics, Leiden University Medical Center, Leiden, The Netherlands, Departments of 2 Bioinformatics, 3 Cell Biology & Genetics and Hematology, Erasmus University Medical Center, Rotterdam, The Netherlands.
منابع مشابه
Gene expression profiling of minimally differentiated acute myeloid leukemia: M0 is a distinct entity subdivided by RUNX1 mutation status.
Minimally differentiated acute myeloid leukemia (AML-M0) is defined by immature morphology and expression of early hematologic markers. By gene expression profiling (GEP) and subsequent unsupervised analysis of 35 AML-M0 samples and 253 previously reported AML cases, we demonstrate that AML-M0 cases express a unique signature that is largely separated from other molecular subtypes. Hematologic ...
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